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Biography: What Publishers Are Looking For. Edited transcript of the panel discussion at Swedenborg House, 24 February 2011. NICK CLEE, chair : Andrew Lownie, founder of the Biographers? Club, has an increasingly indispensible feature each year in his newsletter called ?What Editors Want?. The latest had contributions from thirty editors at leading publishing houses. I say increasingly indispensible because we?re very conscious as authors of having to tailor what we submit to publishers ever more closely to the market. That Essay. By the market I mean three markets.

First, commissioning editors, then retailers and finally the reading public. These markets are changing rapidly and it?s hard for writers to keep tabs on them. Martin Luther King Jr Civil Quotes. But with the help of Inventions Changed History examples, our panellists, by the end of the evening we?ll have a clearer idea of at least one of them. Of Obama’s. JOHN BLAKE, independent publisher. If you have a huge cheque book you can pay ?2 or ?3 million and sign up Tony Blair, then hire a fabulous writer and Industrial that Changed Essay examples, redraft and 1984 schmoop, rework until it?s a polished biography. Changed Examples. It?s an exciting and wonderful area of publishing but it?s a very long way from where I am. As a small publisher we?re constantly having to reinvent ourselves, especially with fewer bookshops but more supermarkets stocking books.

One of the developments we?ve been involved in Listening Essay, during the last year or so is the incredibly fast turnaround book. It used to take around six months to produce a book, since authors wanted twelve weeks to write it, followed by three months to publish. Twelve weeks? writing is now a luxury. On the day Michael Jackson died, one of my authors called and said she wanted to write a book about him. At first I said no, then a few shops began calling and said if we had any books on him they?d definitely to order them. So she wrote his biography in eight days. It was in the shops less than a month after he died ? and Industrial Inventions Changed, it was well-written and researched and went into the top 10. Effective Listening Strategies Essay. If you?re speedy and a good biographer, you?re worth your weight in gold to a publisher. My biggest successes are completely left-field books, which have often been widely rejected by other publishers. My first number one bestseller was about an old East End bare-knuckle fighter called Lenny McLean, known as the Gov?nor.

I?d never heard of that History examples, him. It was 1998 and the book had been rejected by various publishers, then the ghostwriter came to me and Effective Essay, said Lenny was dying from a brain tumour and wanted to see it published for his children. I met Lenny for lunch on Inventions Changed History Essay the King?s Road. Then I caught a taxi home and the driver said, ?Was that the Gov?nor you were with? He?s a legend. You can have a free ride.? We printed 3,000 hardback which sold out in three days. Rhetorical Analysis Of Obama’s. At that time, the perception was that blue collar, working-class men didn?t buy books. But because we gave those men something they wanted to Changed examples, read we ended up selling abut 250,000 copies and spawned a whole new genre.

More recently, Katie Price?s first book was rejected by about six publishers. On Insufficient Of PTSD. This particular title was aimed at men and included a lot of photographs of her without her top on. We felt if they wanted to see those kind of photos they?d buy the Sun . We decided it was more of a woman?s book and that Katie was rather nice but Jordan was a bit of Industrial that History Essay examples, a demon, so we called it Being Jordan and aimed it at women. It sold around a million copies. The point is that the mainstream publishers didn?t see her coming. There weren?t any books aimed at glamorous working-class women and we filled that need. I?d advise you to think outside the regular and find figures who are liked, but before the press has got hold of them. Martin King Jr Civil Disobedience Quotes. If a subject has worked once it will probably work again. Likewise if it failed it will probably keep on failing. Industrial Inventions Changed History Examples. I?ve tried three or four times to publish books about canada health act 5 Mick Jagger and they always bombed.

Whereas, people love Michael Caine and any book about him will sell in enormous quantities. The reading public has an endless fascination for that Changed History intriguing and likeable figures. Equally there are people they just don?t care about. HEATHER McCALLUM, Yale University Press. Generally speaking, it will come as no surprise that Yale?s parameters and emphases are less strictly commercial than John?s and my other colleagues here. Having said that we do commission for the general market and virtually none of our books is strictly scholarly. We expect people outside the academy to Analysis First as President, read our titles, though they do have to Industrial that Changed History Essay examples, meet certain scholarly criteria and proposals and manuscripts are peer reviewed. Luther King Jr Civil Disobedience Quotes. Many of our biographies would be considered relatively traditional in Inventions that Changed History, both selection of subject and approach to material, and are of familiar and significant figures with a clear line from birth to death. Rhetorical First. An example is our ?Lives of the Inventions that Changed History Essay examples English Monarchs?, produced to on Insufficient of PTSD, be the definitive account. They are vastly researched, and I laughed when John said it takes his authors twelve weeks to write a book ? it?s more like twelve years for ours.

These books stay on our backlist for ever. They may not sell in huge numbers but they do sell respectably, at around 2,000 copies a year. As well as historical biography ? and I should say all our biographies are of Inventions, dead people ? we also have a line in health principles, musical and artistic biographies and some literary, which is a very tough sell these days. Nearly all have name recognition. History. The author must have something new to say and A Comparison, new sources ­? reheating the same primary and Industrial Inventions that Changed Essay, secondary sources with a bit of Essay Victims, spin won?t pass muster. And of course they need to be well written with a strong sense of time and Industrial that Changed History examples, place. Increasingly our authors are looking at different ways of canada act 5, approaching traditional figures, such as group or comparative biographies. Inventions That Changed History. An example of this is Churchill and Ghandi, which did really well in the States. Or taking a chunk out of Essay on Insufficient Treatment of PTSD, someone?s life, such as Stalin.

No matter how brilliant a life, it must have a broader significance and must have a longer-term importance. These books need to Industrial that Changed, throw light on the person and Rhetorical Analysis, the age, so that context is richly understood and deployed to illuminate the figure. A really good example of this is Thomas Cranmer by Diarmaid MacCulloch, which makes great use of the Tudor world. I?m making it sound as though we play terribly safe but this isn?t always true. We publish some complete unknowns when we?re sufficiently convinced by the material and Industrial Inventions that examples, the author. Of Obama’s Two Speeches. So what kind of Inventions, authors are we looking for? It?s true that both the name of the subject alongside a known writer will get better coverage and sales, the vast majority of our authors are not well-known. And that?s good because we enjoy building up authors and establishing a platform. For us it?s the quality of the material and how it fits with our list.

These writers will know their field but might not have written a biography before, but they have expertise. You need an empathetic sense, and writers who fall out with their subjects and find them contemptible make it very difficult: the whole sense of encounter with your subject is really important. As for A Comparison of Eukaryotic and Prokaryotic submissions, we don?t read full manuscripts, we prefer standard proposals with sample writing, hooks and suggestion of content. There is still a good market but the glory days of Georgiana and the de Medicis are receding. Overall, we?re more likely to take a risk ? which sounds perverse from Yale?s safe stable ? because our expectations are not massive. We?re influenced by what we like and are swayed by the excellence of the that History author and the project.

Having said all this, our bestseller in the last few years was a Life of Dickens, which proves it?s very hard to escape the famous subjects. PAUL SIDEY, Hutchinson : I certainly admire John?s twelve-week turnaround plan. Act 5 Principles. The first book I ever published was Prick Up Your Ears , a very challenging title by John Lahr, and that History examples, that was five years between the writing and king jr civil, paperback and was a huge success. Since then I?ve done books from Charlemagne to Jimmy Goldsmith. Industrial Inventions That Essay Examples. In recent years I?ve concentrated more on biographies and showbiz, an area increasingly hard to publish.

Only a few years ago you could get a serial rights deal for ?30,000, having not paid as much as that for the book. Listening. Now it would be about ?2,000. I?ve just published a biography of Inventions that Changed History Essay, Joan Crawford. In the old days this particular author, Donald Spoto, was getting ?250,000 for a book on Marilyn Monroe; now he?d get around ?10,000. He can survive because he sells his books around the world. And that?s the key, but unlike John [Blake] selling in supermarkets, we still depend on canada traditional outlets, which are disappearing. We have no high street any more, what we used to call the Inventions History carriage trade ? they?ve walked off somewhere else. As this diminishes, books will come out in a different form, such as digital.

Equally, there is Effective Listening Strategies, a change in readership and knowledge. Years ago we were all familiar with old singers and old films and we knew all the songs and names. I was recently offered a biography of Jean-Luc Godard. I conducted a straw poll around the Industrial that Changed History office and only one young colleague recognised the name. She said, ?Yes, I know who he is: he?s captain of the martin king jr civil disobedience quotes Starship Enterprise.? I was also offered Lesley Caron?s autobiography and someone in the office asked: ?Who does he play for?? Ludicrous but that?s the world we now live in. Industrial That Changed. ALAN SAMSON, Weidenfeld Nicolson : Firstly, let me say what a diverse genre biography is. Charles Darwin, not one of 1984 schmoop, life?s underachievers, wrote a biography that was 130 pages long.

Jean-Paul Sartre wrote a magnum opus about Flaubert and the first volume on his childhood and adolescence is 638 pages, and the remaining runs to 2,400 pages. Inventions That Changed Essay. John Blake has broken the mould with Being Jordan and The Gov?nor , but I would take issue with him on one thing, which is canada act 5, ?likeability?. I think that?s completely changed. When I was a young editor, a typical memoir would be rather badly ghosted, with a series of celebrity anecdotes about dancing with Sammy Davis Junior or having tea with Prince Philip, and everyone was lovely. The culture has changed, now you go on a journey with the celebrity, there are obstacles and Industrial Inventions that Changed examples, setbacks. It may be a painful divorce or an illness or it may be a bad haircut, but there are obstacles to martin king jr civil disobedience quotes, overcome. And by Inventions that Changed no means are all these people likeable.

In our lifetime we?ve seen a whole genre morph into something else. Trevor Dolby is sitting in the front row here . . . he signed up a book in 1995 or 96, A Boy Called It by Dave Pelzer, which inadvertently created the whole misery memoir phenomenon. Before misery lit there was Catherine Cookson and Josephine Cox telling very grim tales about A Comparison Essay Lancashire mill workers? daughters who?d been done wrong . Industrial Changed Examples. . . it was rags to rags. Canada Act 5. And suddenly ? and this is the cultural point ? notions of authenticity are now critical. Industrial That Examples. I don?t think it?s about likeability; I think authenticity is the key to Rhetorical of Obama’s First, success. That History Essay. And the key is to admit that you had a pretty miserable childhood, that you had obstacles, as we all do. And I?ve found that the autobiographies that succeed dwell on childhood and adolescence. Julie Walters, for example, spent most of Rhetorical Analysis of Obama’s First Two Speeches as President, her book on that History her childhood in the Midlands and 1984 schmoop, her struggles as a young actress. That History Essay Examples. Another is Paul O?Grady.

His first volume is about his childhood. We?ve all had childhoods but we haven?t all been famous, and where the celebrity?s life has diverged, and they?ve gone from the ordinary to Effective Essay, the stratospheric in some cases, is the Industrial that Changed core that interests readers. I publish about four literary biographies a year. They?re cradle to grave and for the most part they don?t succeed in sales terms but they?re well worth doing. I have to publish a Keith Richards or a Julie Walters to pay for them, and I very consciously do that. The only way we can get these very excellent books out A Comparison and Prokaryotic is by Industrial Inventions examples cross-subsidising them. And the Listening Strategies Essay way out of that examples, this ?cradle to grave? challenge is to find the Amadeus or Longitude factor, where you focus on an essential conflict and canada health, weave the foreground and Industrial that Changed History, background into canada act 5 principles, the conflict. Changed History Essay. I don?t think the market is 1984 schmoop, there anymore for the 600-page biography when the information is available on Google or Wikipedia.

It?s the parts of Industrial that Changed History Essay, a life you don?t know, the childhood and so on, that you can?t get from of Obama’s First as President search engines. That Changed History Examples. These are the elements that matter. NICK : We?ve seen certain celebrities all over 1984 schmoop, the tabloids but the book bombs. Do you have a theory why certain personalities sell books and others don?t? JOHN : It?s alchemy. Paul O?Grady, for Inventions Changed History example. We published an unauthorised biography that sold in enormous quantities because people are captivated by him. Then there are other people such as Sadie Frost who is all over canada act 5, the tabloids and in magazines, was married to Jude Law and Gary Kemp, but the public doesn?t really care about Inventions History Essay her or like her.

When Prince Edward got married there was press coverage and of Eukaryotic and Prokaryotic Cells, colour supplements everywhere but the book sold around a thousand copies. It?s interesting that sometimes the papers are bang on the money and at Inventions Changed, other times totally wrong. The public couldn?t care less about Edward and Rhetorical First Two Speeches, Sophie. NICK : Heather, are your marketing and PR departments less involved in the acquisition process than at Inventions Changed History Essay examples, other publishers? HEATHER : We have sales projections but Yale is A Comparison of Eukaryotic, a much more editorially driven company.

We take on some books that are cross-subsidised but mostly we do expect books to make money, but not in the hundreds of Industrial Inventions Changed, thousands. We know we?re in Analysis of Obama’s First, an exceedingly privileged position. NICK : In the past, the way to publish many historical or literary biographies was to pay unfeasibly large advances because authors couldn?t write them otherwise. Is this model increasingly under threat? ALAN : Recently an agent was offered ?25,000 for a biography, which is Industrial that Changed Essay, quite a lot these days, and she said that the author lived in a mews house in Chelsea and Essay of PTSD Victims, had a son at Westminster and Changed History Essay, couldn?t possibly afford to accept ?25,000.

I said, in a polite way, ?Tough.? It really isn?t the publisher?s problem. We?re a commercial organisation and not here to subsidise or pay a salary to writers. That model is now under scrutiny, and some good books will not be written, but the notion of an author sitting at home writing is probably long gone. PAUL : I agree that it?s impossible to fund books that don?t have a audience. On the of PTSD Victims whole, if you look at the figures for Inventions History Essay an average historical biography ? and they?re even worse for Treatment Victims a literary biography ? you?ll sell about 3,500 copies. I?d love to publish these books but there isn?t an outlet for them. NICK : How often do you have to examples, say no to books that you would love to Listening, publish, and is it increasing?

JOHN : If the Industrial Inventions that Changed author is prepared to take a realistic advance we?ll fight tooth and nail to Listening Strategies Essay, publish. This month I had phone call from agent who had an author with a wonderful story to tell. Within an Changed History Essay hour we?d agreed an advance of ?25,000 with no synopsis, no details. Purely on this one conversation, and based on one chapter, we already have six-figure offers coming in Listening, from newspapers. Industrial Inventions That. It was intuition. Analysis As President. We rarely turn down books we think will be commercial. HEATHER : We get a lot of Inventions History, submissions and A Comparison and Prokaryotic, we have to turn down books that have no market at all. PAUL : There are plenty of books I was passionate about and would love to have published, but at meetings [with sales, marketing, rights, publicity et al], I have to submit to a Star Chamber inquisition, and if you can?t get a book through that meeting it?s had it. ALAN : John has a certain freedom to publish, and even though some of us have deeper pockets, we have other restrictions. Not only Industrial Inventions that History Essay because you see an Effective Listening Strategies Essay anniversary ahead but because you feel there?s something in the air, the tendency is for the editor to History Essay, want to break the 1984 schmoop mould but the sales people want to repeat recent successes. The frustration is Industrial that Changed Essay examples, when you sense the tide is turning and Analysis Two Speeches, the world is moving in Inventions that Essay examples, a different direction and you think, ?If only I could get this book through this meeting I know it will sell.? Unlike popular science, with history, and perhaps it?s because of the quotes way history is taught, everyone wants the First and Inventions examples, Second World Wars, the slave trade or the Tudors.

Then you get a brilliant book on Walpole?s first cabinet in the 18 th century and because no one teaches the 18 th century you?re told it won?t sell. History is the oddest subject because people want more of the same but they don?t want to fill the gaps. QUESTONS FROM THE FLOOR : The role of agents, how important are they and does the panel consider scripts that come out of the blue? JOHN : With fiction you?ve got to have an agent or you won?t succeed. For non-fiction, if an idea is good it grabs you and these writers don?t really need an agent. They might get an auction going, but I?ve had more than a dozen books where I half-liked the Rhetorical Analysis Two Speeches book and the writer was rather nice, then the agent comes in and goes on and on and gives you ten pages of additions and revisions, and you think ?Life?s too short for this rubbish.? So agents can kill deals as often as they make them. There are many brilliant and creative agents but if your idea is sound it will sell on its own. HEATHER : We deal with agents far less than commercial publishers.

Between 20 to that History examples, 30% of of Eukaryotic Cells, our books are agented. You develop relationships with agents and Industrial History, frequently they bring us ideas that we wouldn?t find elsewhere. They?re quality control and submit better proposals than from unsolicited approaches. In terms of obstructive agenting, there are times when you think ?Yes, I can work with this writer?, then the agent comes in and you suddenly feel you can?t be bothered or it?s not worth your while. There is definitely a role for agents, but for us they?re not essential.

PAUL : I?d agree they?re not absolutely essential but around 90% of our business is with agents. Most publishers are now scrupulous with contracts and agents are useful for this, as well as having the Rhetorical of Obama’s First as President sophistication to look at other markets and drive deals forward. On the whole, I?d recommend you have a good agent. ALAN : I?d like to turn this slightly on its head and say that about 20 to 25% of our books are our ideas, and we go to agents in search of the right author for the project. I receive around 3,000 unsolicited submissions a year and Inventions Changed examples, another 3,000 from agents. I look at the agented ones first. Cells Essay. Having said that, the good unsolicited proposal stands out a mile. Inventions Changed History Essay Examples. We publish maybe one or two out of the 1984 schmoop 3,000 unsolicited each year. I?d say you?re reducing your chance of being taken seriously if you don?t have an agent. The odd thing is, in Inventions Changed History Essay examples, my experience, is that some of the unsoliciteds are among the Listening Strategies best books I?ve ever published. Perhaps it?s the effort they had to Industrial, make, the needle in the haystack that makes them a gem.

They are exceptional books and for the most part are still in print. Some leading publishers won?t look at and Prokaryotic, unagented submissions, but you?d have to be pretty curmudgeonly to ignore all that hard work. PAUL : I still do it, but maybe it?s an old-fashioned thing. HEATHER : We do too, and we also go to agents with an idea for a book. JOHN : Less than 20% of our books come from agents. We don?t pay huge amounts of money but we do open the door and give people a chance as long as we think the book is commercial. Inventions That History Essay Examples. QUESTION : How important are proposals and should they include synopsis, chapter breakdown, sample chapters and Rhetorical First as President, so on? ALAN : The difference between the level of Industrial Inventions that Essay, proposals is astonishing. Some are back-of-the-envelope and full of luther king jr civil disobedience quotes, spelling mistakes, while others are 100 pages, which is certainly the American way ? they?re far more extensive and detailed than the English equivalent.

We tend to Industrial Inventions that History Essay, follow our hunches but it really does help to have a detailed proposal because it shows commitment and organisation. Although I have bought books based on a couple of pages, at Orion we?re encouraged to get detailed proposals, in Effective Listening, part because we need to show them to our colleagues. JOHN : If you get three pages from someone you know that?s fine, but in general the more detailed the better, since you have to convince your colleagues. HEATHER : Agents work very hard to give us thorough proposals and it?s something we really value since for us content is very important. That History Essay Examples. JOHN : What I dread is complete manuscripts.

Your heart sinks because you don?t have time to read the whole thing, but you do want to know what it?s about and where it?s going. A Comparison Of Eukaryotic And Prokaryotic. With certain books you can sum it up in one page, and generally I?d say keep it short because it needs to Industrial that Changed History, grab me straightaway. But whatever you do please don?t write things like, ?Diana Ross has two million fans across the globe and if 10% buy the book it will be a bestseller.? It?s always annoying and will get sent straight back. Say what the book is about, not why it might sell. QUESTION : How do publishers see themselves in the e-publishing/digital world? PAUL : It?s just another way of distributing work. It?s the bookshops that have trouble with this, but the product is Rhetorical of Obama’s Two Speeches, still the same. Inventions. ALAN : The challenge is for high street retailers. Cells. As publishers, we?ve got to reach the Inventions that History Essay examples maximum number of canada health principles, readers, and if that?s through digital and downloads that?s fine by us. In the Inventions Essay 1930s it was the paperback and now it?s digital, but it won?t kill off hardbacks. In fact, a lot of people are buying both.

It?s probably no surprise that our biggest download was the Keith Richards biography, about 4,500 last year and it was the only non-fiction title in martin king disobedience quotes, the top ten downloads in our company. It?s still a small part of our business but it?s going to completely change in Industrial History Essay examples, the next two years. A Comparison And Prokaryotic Cells Essay. HEATHER : The number of books that have sold well for us in e-publishing ? and again it?s a tiny proportion of sales ? might be higher than in the general market because our books are seen as reference and perhaps essential in some cases. JOHN : What?s sad is that we all love bookshops and with e-books you can?t stumble across glorious treasures the way you would in a shop. ALAN : For biography, there?s a sense that you should title the book with the subject. Years ago there was a biography of Shelley called Ariel . If you?re browsing in a bookstore you?ll find it but you probably won?t find it browsing for e-books. Biography titles need to include the name of the subject. That History. NICK : The retail price for martin luther king disobedience quotes the Keith Richards was a lot lower than the hardback. How will publishers survive in a world where e-books are so much cheaper? ALAN : In America and Industrial, Australia they?re well ahead of us and in some cases, particularly with fiction, the e-book has overtaken the paperback sales, never mind the 1984 schmoop hardback.

It?s a brave new world. QUESTION : How do you distinguish between trade and academic? HEATHER : Even our most commercial books are of a scholarly standard but on the trade side we publish books that we feel have a broader market. It?s not a distinct division, we?re not big enough for that. It?s also the Inventions that Changed History case that some trade books turn out to be academic, and vice versa. 1984 Schmoop. It?s an inexplicit art. Industrial Inventions Changed History. QUESTION : Is it ever worth it to self-publish first, then approach a publisher? JOHN : I?ve fallen love with books that people have published themselves and then taken them on to new heights. I?m not sure it?s the same with e-books though. If there are millions of titles out there, how are we going to filter them? ALAN : Our most famous examples of this are The Midwife which became number one paperback bestseller, and Belle de Jour . Overall, I?d say the grail isn?t there yet.

QUESTION : How important are youth and good looks in getting your book published? ALAN : It?s true with certain kinds of fiction, such as chick lit, but with historical non-fiction or biography it wouldn?t remotely influence us. Martin Jr Civil Disobedience Quotes. The quality has to be on Industrial Inventions Changed History Essay the page and the rest is a bonus, but it wouldn?t affect a publishing decision. QUESTION : Is the panel concerned about unauthorised biographies in Rhetorical of Obama’s First Two Speeches, these times of super injunctions, data protection and Changed History examples, libel cases? JOHN : We publish a lot of Effective Listening Essay, unauthorised biographies and we try to Industrial that History, show the manuscript to luther jr civil disobedience quotes, the person involved.

There was a book about Industrial Inventions Changed History Essay examples Bernie Ecclestone a while back which someone had paid a very large advance for and then said it was unpublishable when he threatened to injunct. It was offered to somebody else but they gave up when there was an injunction. Then my friend Robert Smith [agent] persuaded me to take it on for ?1,000 or so. So I wrote to Bernie Eccelstone and said, ?You keep injuncting this darn book, do you want to see what it?s about?? He wrote a note saying, ?You cheeky so-and-so. Canada Principles. Send it round.? His only objection was that it didn?t have enough funny stories in it. So we added some and he was fine about it. If you treat them in a fair way, rather than sneaking around, most people are pretty reasonable. ALAN : Not only libel but the laws of Inventions Changed Essay, privacy become much more challenging for martin king jr civil quotes unauthorised biographies. There was a whole range of that History, books that I published in the 80s and 90s that I wouldn?t do now for legal reasons. We?ve become more of an ambulance-chasing culture. With the Keith Richards book, I never thought that Mick Jagger or Marianne Faithfull or someone like that would sue.

My fear was that the roadie who?d had a spliff with Keith in the back of a car and who was now the mayor of . . . might sue. Effective Listening. Or the woman who was quite a naughty girl in Inventions that Changed, the 60s and is now a headmistress. PAUL : I?m publishing a book on the Duchess of Windsor in April and you?d have thought we?d be relatively safe but the legal reading has been industrious to say the least. Several years ago I did a book on Mohamed Al-Fayed and Rhetorical Analysis of Obama’s, Tiny Rowland and their conflict and we were sued by both of them. NICK : I?d like to end by asking the panel how generally optimistic you are about publishing and Industrial Inventions that Changed History examples, particularly biography? JOHN : Books are a bit like movies in that I won?t go to the cinema for a few months then suddenly there are several films I want to see, such as The King?s Speech , True Grit and Black Swan all out at the same time. If you produce books people want to read they will beat a path to your door. Even without marketing, if you have a good book people will want it, but you have to give them books they want to read. HEATHER : Yale has been slightly insulated in that our imperatives and our market are different.

Quality will out, and if a book is truly excellent there will be a readership for it. It?s very heartening when that happens. Analysis Of Obama’s First As President. PAUL : I really want to keep the optimistic line going . Industrial Inventions That History Essay Examples. . . I?m publishing five biographies this year. The first two haven?t sold that well, but I have hope for the other three. ALAN : Biography is changing and perhaps should change a little faster. Since the terrible period from 2006 when Ottakar?s folded into on Insufficient, Waterstone?s, then Borders collapsed and we saw the virtual end of British bookshops ? it?s an Essay examples awful time in terms of retail. But this doesn?t mean that great books aren?t being written and published. This event was a full house of 100 guests, nearly all of them writers.

We were encouraged, enlightened and occasionally alarmed by what the king jr civil disobedience quotes panel had to say. Once the Forum on Industrial that the Noticeboard page of our website is running (and apologies for on Insufficient Victims its temporarily complex format), please add your views and feedback for debate.

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Find your industry and get a few detailed tips on how to structure your own cover letter. RG I must say this helps me a lot. Not sure if I could master it but this would definitely help. Thank you so much for making my day 3. We are really glad to hear that and A Comparison and Prokaryotic Cells thank you for Inventions Changed Essay, your support. Please let us know if you have any question.

I remain stumped as to how to address a cover letter in response to a job advertisement that gives neither the company name nor the name of the person in charge of act 5, hiring. This is true of many job postings on Industrial Inventions that History examples Craigslist, for canada principles, example. I dislike “To Whom It May Concern”, but what other greeting would you recommend? Many job seekers also run into that History examples this issue. When the posting doesn’t include a name of the company or hiring manager, try copying some of the health job description and searching for it on Google. Inventions That Changed History Essay. You may find the job ad with the names included. If this doesn’t work, then it is acceptable to address the cover letter with “Dear Hiring Manager.”

Good luck on the job hunt, I normally just put Dear Hiring Manager. I’ve had issues where you call and there are multiple people who do the hiring, so I don’t know who will be doing my interview until the day I have my interview. If I ask the employee there like, “Oh I’m not sure.” I’m going to Rhetorical as President, forward this to Changed Essay examples, a client of mine I was just talking to him about this. Of Eukaryotic And Prokaryotic Essay. Now he’ll know that I’m not just trying to make his life miserable.

Great! We hope they find our resources helpful. I have done my resume and now I’m preparing myself to do CL, but I have problem with it, because everything is wrote in Industrial Changed Essay examples resume – especialy introduction. It would be the best if I could copy my introduction from resume to Cells, CL, because there is almost the same to write. please advise. Some of the Inventions that History Essay contents from your resume intro should be used in you CL, but should not simply be copied.

If you read the above guide and download the template pack, you will learn exactly what information should be included. Two Speeches. Also, be sure to check out our CL samples to give you a better idea on how you can word your cover letter. Good luck on the job hunt! I am trying to write a cover letter for a managerial position in the hospitality field. However, I do not see any examples.

We are in the process of Industrial Inventions Changed, adding new cover letter samples and have included your suggestion in the list. In the meantime, follow the guide above and download one of of Obama’s First, cover letter templates. Good luck on Industrial Inventions History Essay examples the job hunt! Basically, a cover letter is a letter of of Obama’s Two Speeches, introduction. Inventions That Changed History Essay. Usually I state the martin king name of the position I’m applying for and why I am qualified for the position. At the end of the letter, I’ll write something like “If you have any questions or to schedule an appointment for an interview, please contact me at ***-**-****.” Then double space and type “Sincerely” and then space 4 times and type your name. You’ll be signing in the space above your typed name. This has been most helpful. GBU.

Glad you liked it. Industrial That Changed Examples. Share it with you your friends. Effective. GBU, too! I am working on a resume for an experienced welder, One of the requirements is a valid drivers license, which I do not possess at this time , but if I was hired, I could pay the traffic fine and get my license back with my first paycheck. Should I explain this on that Changed my resume or by telephone or in person or not at Rhetorical Analysis of Obama’s Two Speeches as President, mall. In all honesty, your best bet is to find a way to pay the traffic fine and get you license back before applying for the position. Thanks for the advice. Industrial That. I was thinking that very thing or appearing at traffic court and setting up a payment plan which would clear the way for a re issue. All about the money. which I happen to be in short supply of. Thanks again. We know the struggle.

Hang in there brother! Try add figures that will impress an employer and that pertain to the position you are applying for. Best of luck! I live in Thailand and odd numbers here are auspicious so it probably won’t hurt to throw some of them in. I’m still not sure what you all are referring to with bullet point ‘numbers’. Can someone explain? Thank you. thank you so much RG you really shade light on cover letters, i was clueless wat it was so mostly i would ignore it and send my applications without one from today i will do thngs differently. Download our cover letter template pack and use the tips written above. That should get you started.

Best of luck! How to address gaps in employment. Of Obama’s. My mom passed away unexpectedly in 2005. Essay. I was incapacitated by depression and unable to work from 2005-2008. Got a job in act 5 principles 2008 was employed until 2012 when I had a baby. i have been a stay at home mom. Ready to go back to Inventions that History, work again. How do I address the gaps when posting my resume on job resource sites? I have spent the past six months working reworking my resume. A Comparison Cells. I’ve searched hundreds of resume websites; Resme Genius is, by far, the best. Would appreciate any advice.

Thanks for the kind words. One of the easiest ways to mask your work gaps is to use a functional format: https://resumegenius.com/resume-formats/functional-samples-writing-guide. Give it a try and see what you think. Good luck on the job hunt! How do explain a reason for leaving a company when you hate your job/employer, more management than the job itself. We always recommend not to burn any bridges with former employers and to leave on Inventions Changed Essay examples a positive note. So in that case, we suggest that you explain that you are looking for an opportunity in a new industry or a different position. Although it may sting, make sure to also thank management for the opportunity you were given. Good luck!

Struggling with how to Effective Strategies Essay, address a cover letter for a summer internship. I’m not applying for a posted internship, just going to show up at Inventions History Essay examples, an organization that my school advisor suggested I reach out to. I have no idea who I’ll be giving my cover letter to, but I don’t want to say “dear hiring manager” because technically they wouldn’t be hiring me… right? Aside from act 5 that, this guide was still very helpful. We’re glad that you found our advice helpful.

In your case, “Dear Hiring Manager” or “Dear Madam or Sir” would be appropriate. Good luck! So i have been asked to Industrial Essay, email my salary requirements, Here is my situation though, I previously worked with this company in the same exact role. I left for another job opportunity ( which built my skill set and experience) about a year ago this month. They have asked me to come back and fill that position again. How do I compose a salary requirement. In this situation you have the leverage, so it would be fair to ask for 10-20% more than you were paid before. The skills and experience you gained over the last year make you more valuable than you were before.

Good luck! Hi, I am trying to help a friend who is martin luther quotes, looking to move into a completely different line of work, he has only had 1 job since high school, which has nothing to do with what he really wants to that, do. How do you approach that in health act 5 a cover letter, since he has no experience in the field? Your friend will have to discuss their general skills or traits that are relevant to the job. I just turned 62 and want to retire from my current job, but not ready to retire. Industrial. Any suggestions on how to “put my best foot forward” when applying for a new position in on Insufficient Treatment of PTSD an industry I’ve never worked in before? When applying for Inventions that, a position in an industry that you’ve never worked in before, the first thing you should do is canada, come up with a list of the relevant skills that you can transfer over to that industry. Inventions That Changed Essay. From there, you can work on ‘selling’ those particular skills in your cover letter and martin luther disobedience resume. Good luck! So glad I stumbled upon this.

Glad you found it helpful! I’m applying for a new job but the mining company has different projects. Would I have the company’s address or the project site address? We recommend that you use the address that the cover letter is being sent to. If you are not sure, then use the company’s address. Good luck! Some cover letter here have helped me move on to another level. Through this i had to that Changed Essay, pay bills for my ailing child . Thanks you have been of great help through the way to write a winning cover letter.

Great information! My question is I have been out of the and Prokaryotic Cells Essay work force for about a year and a half due to birthing children and staying home for them. I am wondering if this is something i should include on my CL to explain my gap in Industrial that Changed Essay examples work history or is this information to personal to include? Great question! If your work gap is longer than a couple of months, then you should certainly include an Essay Treatment, explanation in your cover letter.

Don’t spend more than 1-2 sentences on your explanation though. Remember that you want to keep the focus of your cover letter on your experience and that Changed History Essay qualifications. You can say something like “After taking some time at Rhetorical Analysis of Obama’s as President, home with my family,” then express how excited and Inventions Changed History enthusiastic you are to return to the work force and how this position is exactly what convinced you that now is the time to martin luther quotes, do so. You can use that phrase for maternity leave, or caring for older family members, or even your own issues. Shoot, you can use that even when you didn’t choose to take a break, so to speak. Good luck! I’m a college dropout and I couldn’t decide on which template to use for my cover letter. I quit school during my sophomore year.

We suggest using the ‘Non-Student’ templates. If your college experience is relevant to the job you are applying for, you might consider including it your cover letter. Best of luck on Industrial Inventions that History Essay the job hunt! Thank you Resume Genius! what if there is Effective Strategies Essay, no job description given? how do you start of with the cover application in such a scenario? Even without a job description you can still follow the template above. Look up job descriptions for the same position from other companies to get an idea of what the employers is looking for. Unless requested in the job ad, leave your salary requirements off your cover letter. Good Luck! Fair point – it’s always good to that Changed History Essay, be careful when sending out personal information.

Thanks for canada health, the suggestion! Share How to Write a Cover Letter #038; 40+ Free Templates Our code geeks and HR experts are proud to introduce our new Free Resume Builder software to help you land more interviews in today’s competitive job market. We provide HR-approved resume templates, built-in job description bullet point phrases to choose from, and easy export to MS Word and PDF. Get awesome job opportunities sent directly to your inbox. By clicking Send Me Job Alerts, I agree to Changed History Essay, the Resume Genius Terms of Use and Privacy Policy. Play the One-Minute Game That’ll Show You How to Cells, Improve Your Resume. Think you can judge the quality of a resume within 6 seconds? The answer may surprise you. That Changed History Essay. Put your skills to the test, and learn how to make your resume 6 second worthy!

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What are the differences between the Effective Strategies major online resume builders? Here's an in depth analysis of History Essay, what. Resume Genius' builder, resources, advice and career tips are regularly featured on some of the world's leading online and offline publications including: Our code geeks and HR experts are proud to introduce our new Free Resume Builder software to help you land more interviews in today's competitive job market. HR-proven resume templates, built-in job description bullet point phrases to act 5 principles, choose from, and that Essay easily export to MS Word and PDF.

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16 Free Medical Assistant Resume Templates. There is an increasing demand for medical assistants in the coming years due to aging of the population and History Essay examples, advances in medical technology. According to the U.S. Bureau of Labor Statistics (BLS), the medial assisting field is martin, expected to grow by over 30% between the years 2010 and 2020. Medical assistants are an important part of the healthcare industry as they provide much needed support within healthcare facilities. A medical assistant#8217;s main responsibility is to provide patients with clinical and administrative assistance . Industrial That History Examples? They are employed in medical offices, clinics, and hospitals, and work closely with physicians and specialists.

Their job duties often vary depending upon act 5, where they are employed. That Changed? In some offices, the Cells Essay, medical assistant is in charge of the management and administration of the office, which allows the physician#8217;s time to be spent on providing better patient care. Other times, their responsibilities rest solely on providing patient care. Individuals who choose medical assisting as a career have a lot of responsibility and Changed History Essay, can expect to earn an average salary of between $23,000 and A Comparison of Eukaryotic Cells, $31,000 per year . Although there is NO requirement for MA to have formal training, all employers will have different educational requirements and you might be expected to have at least 1-2 years of Essay formal training at a technical or vocational school or hold an of Eukaryotic Essay, associate#8217;s degree. There are several different types of Industrial Inventions that medical assistants . On Insufficient Treatment? The first type is the clinical medical assistant . A clinical medical assistant#8217;s primary responsibility is patient care, carrying out assessments, and performing other medical tasks. Inventions Changed History Examples? The second type of medical assistant is the administrative medical assistant. The administrative medical assistant primarily performs administrative duties such as managing patient records, scheduling appointments, answering phones, performing general account billing, and maintaining the martin king jr civil disobedience quotes, front desk area. Inventions Changed History? The final type of medical assistant is Essay Treatment Victims, one who has chosen to specialize in a specific field of medicine . Specialty areas could be family medicine, geriatrics, internal medicine, OB/GYN, pediatrics, oncology, transplantation surgery, cardiology, urology, women#8217;s health, endocrinology, or another field. Size: Downloads: 9523 Download: zip and docx Uploaded: 2013-11-13 21:03:00 / 3354. This is that Changed, a general resume that is suitable for a Certified Medical Assistant or a Registered Medical Assistant.

For the most part, writing a Medical Assistant Resume is the same as writing resume for any other job. Your resume should accurately display your knowledge and commitment to the field as well as your desire for employment within the health act 5, field. It should show your professional potential as well as your passion and commitment to Inventions Essay examples, quality care. Include any relevant clinical experience you have as well as experience in specialized areas, if applicable. Maintaining a generalized approach is appropriate if you don#8217;t have any specialty experience. Describe responsibilities you had, duties you performed, and 1984 schmoop, success you achieved at your previous positions.

What is included in your resume will vary depending upon what types of positions you plan to apply for. Inventions Changed History Essay? Make sure you only include duties that are relevant to position you are applying for. Some duties typically found on Medical Assistant resumes: Answer office phones and schedule appointments Greet patients and martin king jr civil disobedience, prepare them for Industrial Changed Essay examinations Obtain patient medical history and vital signs Assist physician during patient examinations Perform routine laboratory tests and administer injections Explain treatment procedures, medications, special diets, or doctor#8217;s instructions Perform electrocardiograms or other diagnostic tests Authorize drug refills and provide prescription information to pharmacies Assist with insurance, coding, and billing paperwork. Good communications skills, empathy, and people skills . These skills are important to help put patients at ease, as well as answer questions about medications, instructions, and tests. Analytical skills . It is essential to understand information on medical charts such as diagnoses, as well as being able to code patients#8217; medical records for billing purposes, if required. Detail oriented and First Two Speeches as President, technical skills . Medical assistants use basic clinical instruments and Inventions Essay, need to be accurate when taking and recording patients#8217; vital signs. If you hold any certifications, licenses, etc., they should be incorporated into your resume to show your dedication to furthering your vocational skills. Here is 1984 schmoop, just one sample Medical Assistant Resume with objective, summary of skills, work experience, and education. As previously noted, the type of resume required for medical assisting will depend upon what type of skills you#8217;ve acquired as well as what type of environment you plan to pursue employment in. A professional resume should be tailored to Changed History Essay examples, portray who you are, what skills you possess, and A Comparison of Eukaryotic and Prokaryotic, be geared towards the type of job you#8217;re looking for . Here we#8217;ve helped to create examples of just how to achieve the perfect resume to fit your needs. You will find three resume formats: chronological (focus on work history), functional (focus on skills and qualifications), or combination (both work history and Inventions that Changed History Essay examples, skills).

Whether you are a recent graduate, or someone who has experience as a medical assistant, you will be able to find one that will highlight your positive attributes and get you started on searching for the career you#8217;ve been looking for. Analysis Of Obama’s Two Speeches? This resume is suitable for someone who has some experience working as a Medical Assistant and has different clinical and administrative skills. Inventions That Changed Essay Examples? Size: Downloads: 7178 Filename: Experienced-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3348. Chronological Medical Assistant Resume. Rhetorical Analysis Two Speeches As President? Chronological resume for someone who is experienced at working as a medical assistant; focus on experience, performed duties, and job skills. Size: Downloads: 2307 Filename: Chronological-Medical-Assistant-Resume.docx Uploaded: 2013-11-13 21:03:00 / 3340. Experienced Pediatric Medical Assistant. History Essay Examples? This is an example of a resume to be used for martin luther king quotes someone who has experience as a Pediatric Medical Assistant. Size: Downloads: 2425 Filename: Experienced-Pediatric-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3350. Industrial Inventions That Changed History? This resume sample provides a generic template which can be used for an entry level medical assistant, or for First as President a certified or registered medical assistant. Industrial Inventions Changed? Size: Downloads: 4627 Filename: Entry-Level-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3344.

This is a basic resume that can be used for luther king jr civil disobedience quotes anyone seeking employment as a medical assistant. Size: Downloads: 3411 Filename: Basic-Medical-Assistant-Sample.docx Uploaded: 2013-11-13 21:03:00 / 3338. This is a medical assistant resume sample that focuses on Essay examples administrative and on Insufficient Treatment of PTSD, clinical skills and experience in orthopedics. Size: Downloads: 1560 Filename: Clinical-Orthopedic-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3342. Inventions That History Essay Examples? Entry-level Medical Assistant Resume. This resume is perfect for an entry-level position for someone who is just graduating and looking for their first medical assistant job. Size: Downloads: 2447 Filename: Entry-level-Medical-Assistant-Resume.docx Uploaded: 2013-11-13 21:03:00 / 3346. Functional Resume For Medical Assisting Field. This is an example of Strategies Essay a functional resume for History Essay examples use when looking for Effective Listening Strategies a first-time job in the medical assisting field. It focuses on skills and that examples, qualifications rather than on work experience. Size: Downloads: 3421 Filename: Functional-Resume-for-medical-assisting-field.docx Uploaded: 2013-11-13 21:03:00 / 3352.

Generic Combination Medical Assistant. This resume can be used whether it’s your first or next medical assistant job. It highlights skills and experience. Size: Downloads: 2205 Filename: Generic-Combination-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3356. This resume contains a summary of Analysis qualifications and is suitable for any medical assistant with some experience. Size: Downloads: 1987 Filename: Generic-Medical-Assistant-Sample.docx Uploaded: 2013-11-13 21:03:00 / 3358. This resume can be used for a student medical assistant who has not worked in the field yet. Inventions History Essay? It focuses on act 5 principles externships and volunteer experience in place of Changed Essay examples work experience.

Size: Downloads: 2360 Filename: Student-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3366. Sample resume for Medical Assistant Intern with example of qualifications, objective, related skills, education, and A Comparison of Eukaryotic and Prokaryotic Cells, employment history. Size: Downloads: 1642 Filename: Medical-Assistant-Intern.docx Uploaded: 2013-11-13 21:03:00 / 3360. This is a resume for an experienced Certified Medical Assistant who has experience as Medical Assisting Extern and Emergency Room Technician Extern. Size: Downloads: 1532 Filename: Medical-Assisting-Extern.docx Uploaded: 2013-11-13 21:03:00 / 3362. This resume is for Medical Assistant experienced in working with pediatric patients, solid Clinical and Administrative skills. Size: Downloads: 1960 Filename: Pediatric-Medical-Assistant.docx Uploaded: 2013-11-13 21:03:00 / 3364. History Examples? CMA with experience in a multi-physician family medical practice and additional healthcare experience as an RPT. 1984 Schmoop? Size: 148 KB Downloads: 2332 Filename: Certified-Medical-Assistant.docx Uploaded: 2015-08-11 21:02:00 / 8222. 855.213.0348 | MON-FRI 8A-8P, SAT 8A-5P, SUN 10A-6P CST. 2017 Bold Limited.

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essay on Essay, hvtn 505 The path forward to an efficacious HIV-1 vaccine will be expedited via the analysis of immune correlates from Effective Listening Essay, past and future HIV-1 vaccine efficacy trials. Approaches that aim either to improve upon current findings from a partially efficacious vaccine strategy or approaches toward the generation of broadly neutralizing antibodies by Industrial Changed rational immunogen design strategies are likely to be fast-tracked through careful probing of the intersections of health principles immune correlate analyses within and among human vaccine clinical trials. When carefully interrogated for correlates of risk (immune responses and host/virus genetics), each of the efficacy trials (failed or partially efficacious) can provide new information to advance the HIV-1 vaccine development field. In some cases, clues about potentially protective immune responses can be discerned, and of equal importance, potentially detrimental or distracting immune responses can be identified.

Immunogen design strategies may benefit from these analyses, such that that immunogens can be paired down to that Changed essential components. Moreover, insights from these studies on how host and virus genetics play a role in vaccine-induced immunity will enable the advancement of immunogen designs toward globally efficacious vaccines across different populations. The intersection of correlate analyses or studies involving immune responses (innate, cellular, humoral), host genetics (e.g., FcR expression, HLA) and HIV-1 virus sieve analyses (virus sequence analysis of all infections (placebo and Rhetorical Analysis, vaccine groups) to Inventions that History determine if there were specific genetic attributes of infecting viruses that were significantly different between the two groups) are areas of the highest information content for follow-up studies (Figure 1). On Insufficient Treatment! In this review, the Industrial Inventions Changed Essay examples, correlate analyses for HIV-1 vaccine efficacy trials are described, with an emphasis on those studies that examine the 1984 schmoop, intersection of different components and analyses. Due to Industrial that Changed History Essay examples the uniqueness of each efficacy trial and martin king jr civil disobedience quotes, outcome, each study can provide information regarding the minimum bar to Industrial Inventions that Changed History examples overcome to achieve HIV-1 vaccine efficacy. Even when there is no overall vaccine efficacy, the Effective Essay, heterogeneity of Industrial Inventions that Essay immune responses among vaccines has enabled follow-up studies to identify associations of immune responses with HIV-1 infection risk in subsets of vaccines. Furthermore, an 1984 schmoop integral part of understanding immune correlates of Inventions Changed History examples protection is to also define patterns of immune responses that associate with non-protective vaccines. Treatment Victims! One of the major goals for the HIV-1 vaccine field is to define correlates of protection from HIV-1 infection, such that the field has biomarkers that will clearly predict vaccine outcome in HIV-1 vaccine efficacy trials. There have been six HIV-1 vaccine efficacy studies to date [1,2,3,4,5,6] (Table 1), each testing either a different vaccine strategy, or different populations with different risk factors and geographic locations. HIV-1 vaccine efficacy studies have been analyzed for correlates of infection risk; however, a correlate of protection for an HIV-1 vaccine has not yet been identified.

Both the non-efficacious vaccines [7,8,9,10,11] and the one partially efficacious HIV-1 vaccine [12,13,14,15] trial have yielded several correlates of Essay infection risk; although more weight is given to those findings from martin luther king, trials where there was overall vaccine efficacy. In total, three of Industrial Inventions Changed History Essay these studies (VAX004, Step, and canada health principles, RV144) found significant correlations with HIV-1 infection risk/incidence and two of these studies (Step and RV144) identified potential sites of immune pressure on the virus (virus sieve). The terminology employed for describing correlates and surrogates for protection from HIV-1 infection have been the focus of ongoing discussion and Changed Essay examples, clarification [16,17,18,19]. It is generally agreed upon that for any one of the martin luther, correlates of infection risk identified in RV144 to Changed Essay examples be considered a correlate of protection that reliably predicts protection from HIV-1 infection, it must be tested and Rhetorical Analysis as President, proven in another clinical trial either with the same setting or in a different vaccine setting [18]. Inventions That Changed Essay! Ultimately, it is the latter confirmation of the correlate to HIV-1 vaccine efficacy in a different geographic region, different virus strains, different risk groups, etc . that is the most sought after for the development of a global HIV-1 vaccine. (Efficacy futility determined at Analysis as President, first interim analysis after full enrollment ) Vaccine-induced immune responses have been studied to identify immune correlations with infection risk and evidence of virus sieve that can inform the design and Inventions that Changed History Essay, evaluation of the next phase of vaccine efficacy trials (shaded boxes indicate reported correlations). A Comparison Cells Essay! Immunizations in two efficacy studies (Phambili/HVTN 503, HVTN 505) were stopped; however, follow-up of participants continues. a Vaccine Efficacy (VE) Outcome is noted as “No Efficacy” if there was no overall statistically significant vaccine efficacy; b MSM: Men who have sex with men; c Participants, meeting enrollment criteria, were enrolled from the general population; d TG: Transgender. 3. Industrial Inventions Changed History Essay Examples! Cellular Immunity and Essay on Insufficient Treatment, HIV-1 Vaccine Efficacy Trials. HIV-1 specific CD8 + T cells are associated with control of HIV-1 replication as demonstrated in acute HIV-1 infection [26,27,28,29,30] (reviewed in McMichael et al. [31]) and in Inventions History studies of health act 5 those rare individuals who can naturally control HIV-1 infection long term [32,33,34,35,36,37]. Inventions That Essay Examples! Moreover, studies in NHP have demonstrated, as proof of concept, that vaccine induced CD8 + T cells can be protective [38,39,40,41]. Victims! In two HIV-1 efficacy trials (Step and Phambili) aimed at inducing CD8 + T cell responses (in the absence of HIV-1 envelope specific antibodies), there was no overall association with vaccine efficacy.

However, these studies indicated that there were vaccine-elicited CD8 + T cells that could impact virus replication; although not sufficient enough to provide overall decreased risk of infection in the trial (either due to low magnitude/breadth/function of T cell responses and/or pre-existing vector immunity etc. History! ). HVTN 505, also designed to target the health principles, induction of CD8 + T cell responses (as well as HIV-1 envelope specific antibodies), was discontinued and unblinded due to lack of Inventions Changed History examples efficacy. Studies of the canada health, magnitude and quality of the CD8 + T cell response are ongoing. Since there was evidence of increased infections in two of the Ad5 vector based vaccine studies, Step and Phambili [42] but not in HVTN 505 [6], there is a greater emphasis on understanding immune responses to vaccine vectors and impact on subsequent immunity. Additional studies demonstrated that there may be some cross-reactivity in the T cell responses among the different adenovirus serotypes that will have to Industrial that History examples be tested carefully going forward as vectors are chosen for clinical trials [43]. An alternate interpretation is that perhaps many other types of HIV-1 vaccines induce some level of CD4 + T cell activation; however, the key is to have sufficient overall HIV-1 specific immunity to of PTSD Victims tip the balance toward protection. Industrial That Essay! Despite these setbacks on understanding how to induce protective CD8 + T cell induced immune responses in human HIV-1 clinical trials, a new paradigm for T cell immunity has emerged from NHP vaccine studies. Picker and 1984 schmoop, colleagues report on a CMV based vaccine regimen that protects NHPs from infection and induces a novel subset of CD8 + T cells that can broadly recognize HIV-1 epitopes through class II restriction [38]. The series of papers by Picker and colleagues provide new hypotheses to Industrial Inventions that Changed Essay examples test for inducing effective cellular immunity, both in terms of both new immunogen vector design and new subsets of CD8 + T cells to target with vaccine approaches.

HVTN 502 (Step) and HVTN 503 (Phambili); Host Genetics and Virus Sieve Analyses. The Step study [3,44] as well as the Listening Strategies Essay, Phambili study [4] were test of concept studies (double-blind, randomized, placebo-controlled) for Industrial Inventions, induction of HIV-1 specific T cells responses. These trials tested the concept of a replication defective adenovirus serotype 5 (Ad5) vector with clade B HIV-1 genes ( gag , pol nef ) (MRKAd5) to Strategies Essay decrease virus load in Inventions Changed History Essay those who became infected. Essay! This vaccine regimen generated antigen specific T cell responses, but overall these responses did not result in vaccine efficacy. An increased rate of HIV-1 infection was observed in vaccines compared to that placebos that was associated with being uncircumcised and having pre-existing Ad5 antibodies (reviewed in Gray et al. Martin Luther Disobedience! [45]). This increased risk was confirmed in follow-up studies that also reported a waning of the increased infection risk over Industrial Inventions Changed History examples, time [46]. Health Act 5 Principles! In order to understand the lack of efficacy (and enhancement of infection in the vaccine group), follow-up studies were undertaken to understand the immunity that was generated by vaccination. One of the goals of these follow-up studies was to examine potentially protective responses that may be subdominant in the population but may impact either acquisition or disease progression in Industrial Inventions that Changed History examples some of the martin luther king disobedience, vaccines. Notably, detailed analysis of the “breakthrough” viruses, or viruses that did establish infection despite vaccine-induced immunity, demonstrated that there was selection at specific sites indicating potential vaccine induced T cell specific immune pressure [23].

Notably, the antigen specific CD8 + T cells responses induced by Ad5 vaccination were to that Essay examples HIV-1 epitope hotspots that were different than those generated in natural infection and were also directed to Effective Essay highly variable regions that likely can tolerate escape mutations from vaccine induced immune responses [47]. Host genetics also played a role in immunity, since those vaccines with HLA alleles (B*27, B*57, B*58:01), known to be associated with HIV-1 control, had lower viral load [48] and their CD8 + T cells exhibited greater killing in in vitro assays [49]. Recent analysis of those infected within a year of their last vaccination, identified that total T cell breadth and Industrial Inventions that History examples, total magnitude of the First Two Speeches, immune response after the immunization series and prior to infection significantly correlated with lower mean viral load [50]. A sieve analysis of the Step trial found that there was significant sequence divergence of the infecting viruses compared to the vaccine [23]. However, despite an that Changed examples observed anamnestic T cell response (from vaccine-induced immunity) after infection, the specific T cell responses measured as part of the evaluation of the trial did not correspond with the sieve findings [51]. Moreover, none of the on Insufficient Treatment Victims, HIV-1 antigen specific T cell responses that were tested were associated with risk of infection in the vaccine recipients [11]. Industrial Essay! Surprisingly, the non-HIV specific ELISpot magnitude was a significant direct CoR for HIV-1 infection in the vaccine group. Thus, sieve analyses along with immune correlate analyses can be informative in generating new hypotheses about baseline or vaccine-induced responses correlating with infection risk. 4. Humoral Immunity and Two Speeches as President, HIV-1 Vaccine Efficacy Trials.

Four of the Inventions that Changed Essay, HIV-1 vaccine efficacy trials induce HIV-1 Env-specific antibody responses by three diverse strategies: recombinant HIV-1 gp120 immunogen alone (VAX003 and VAX004); vector prime with gp120 boost (RV144); and DNA prime, vector boost (HVTN 505). Although VAX003 and VAX004 efficacy trials each tested gp120 protein only as an immunogen strategy to induce humoral responses, these trials were distinct in that they were conducted in 1984 schmoop different risk populations (injection drug users (IDU) vs . Industrial Inventions That Changed History Examples! men who have sex with men (MSM)) and with different clades of gp120 protein immunogens (B/E vs . B/B). Similarly, both RV144 and HVTN 505 were prime boost strategies, but each tested a different vector (ALVAC vs . 1984 Schmoop! rAd5) and in that Essay examples different risk populations (community-based risk in Thailand vs . MSM in the U.S.). It is A Comparison of Eukaryotic Essay, unknown whether the same mechanisms of protection against Industrial Changed History examples HIV-1 acquisition will be similar or quite distinct among the different risk populations/transmission routes. Thus, there are four major differences across these HIV-1 vaccine efficacy trials that need to Rhetorical Two Speeches as President be considered when comparing studies: (1) differences in the HIV-1 gp120 sequence content; (2) differences in the approach (prime/boost and vector vs . protein); (3) diverse infection risk populations tested by each vaccine; and (4) different geographic locations and clades of Changed Essay HIV-1. 4.1.

VAX003 and VAX004: Immune Response and Host Genetics. The VAX003 clinical trial was conducted in Analysis of Obama’s First Two Speeches high-risk injection drug users, and the vaccine contained bivalent gp120 (Clades B and Clade E: AIDSVAX B/E) [2]. As part of the primary analysis of vaccine efficacy for VAX003, pre-specified antibody variables (V2 and V3 binding antibodies to a vaccine strain envelope (A244), gp120 binding antibodies (A244 and MN), CD4 blocking antibodies and neutralizing antibodies to HIV-1 MN) were found not to be correlates of risk. That History! The VAX004 clinical trial enrolled high-risk men and women (predominantly men who have sex with men) and martin luther jr civil disobedience, the vaccine contained two clade B gp120s (AIDSVAX B/B) [1]. Follow-up studies of vaccine-induced humoral responses in VAX004 reported that higher neutralizing antibody (nAbs) responses to an easy to neutralize virus [7], CD4 blocking antibodies [7], and antibody-dependent cellular virus inhibition (ADCVI) [8] correlated with lower HIV-1 infection risk among those in the vaccine group. Neutralizing antibody responses against Industrial Changed Essay more difficult to neutralize viruses ( i.e ., circulating viruses that are the Essay Treatment of PTSD, target of Industrial Essay vaccine strategies) were also induced. However, one interpretation is that this level and breadth of response may be below the bar needed for efficacy (and, thus, providing some information on where the A Comparison of Eukaryotic and Prokaryotic Cells, bar sits) [52]. Comparative studies among vaccine efficacy trials can also inform as to what might constitute a potentially protective immune response. Neutralizing antibody responses were higher in VAX003 compared to that History examples RV144 [53], indicating that higher antibody responses were not by themselves better nor predictive of a positive outcome. Insights from analyses of host genetics suggest that although there was no overall increased infection in the VAX004 vaccine trial, the Fc? receptor IIIa genotype (VV genotype, encoded by Essay of PTSD Victims an allele with a valine (V) a position 158) was associated with an increased rate of HIV-1 infection in low risk vaccines, but not in high risk vaccines [9].

RV144 is the only HIV-1 vaccine efficacy trial in Inventions History which the vaccine showed decreased transmission versus the placebo group, with an estimated vaccine efficacy of luther king disobedience 31% [5]. An international collaborating team of scientists completed a case control study reporting that two humoral immune measurements correlated with the risk of HIV-1 infection [12]. IgG antibodies to the V1/V2 region of HIV-1 gp120 correlated with a decreased risk of infection [12,13,14,15], and a plasma HIV-1 envelope-specific IgA score correlated with increased risk of that Essay examples infection in the vaccine arm (decreased vaccine efficacy) [12,54]. Six primary variables were tested in the correlate analyses: plasma Env IgA score, Env IgG avidity, HIV-1 neutralizing antibodies (nAbs), antibody-dependent cellular cytotoxicity (ADCC), V1/V2 Env IgG and Env-specific CD4 + T-cells. Of Eukaryotic Essay! Overall, humoral responses were the Industrial Changed, predominant immune response in this trial, with evidence of Essay on Insufficient Treatment Victims vaccine-elicited V2 targeted CD4 + T-cell responses [12,55].

One key insight from the evaluation of the RV144 vaccine trial was that the vaccine immunogen was unique in its antigenicity ( i.e . , exposure of specific epitopes) compared to other envelope proteins [25,56]. Studies of the RV144 protein immunogen demonstrated that certain epitopes were better exposed, as a result of an 11 amino acid N -terminal deletion of the AE.A244 gp120 envelope, thus leading to the induction of dominant V1V2 antibody epitope specificities that were well exposed on the vaccine immunogen [56]. In particular, the A244 gp120 used in Inventions that RV144 was antigenic for A Comparison of Eukaryotic Cells, both linear V2 epitopes bound by Industrial that Changed History strain-specific V2 antibodies, as well as for conformational V1V2-glycan epitopes bound by V1V2 broad neutralizing antibodies (BnAbs) [25,56]. Thus, 8,000 individuals have been immunized with an antigen expressing a BnAb epitope, yet only non-glycan-dependent nAbs were induced [12,25,57,58]. Thus, in addition to defining correlates of protection in RV144, a second critical reason to study vaccine responses in RV144 is to understand why BnAbs were not induced by an antigenic immunogen. These findings indicate that careful evaluation of envelope antigenicity ( i.e ., determining what epitopes are exposed for immune recognition) can provide insights into the types of antibodies that may be elicited by vaccination. 4.2.2. 1984 Schmoop! RV144: Intersection of Antibody Epitope Specificity, Antibody Function and Industrial that Essay, Antibody Form. Further analyses of the six primary variables in the RV144 correlate analyses using interaction models was one way of examining the role of multiple immune measurements in assessing correlates of HIV-1 infection risk. The secondary analysis as part of the RV144 immune correlate work [12] indicated (through a statistical interaction model) that in the presence of low vaccine-elicited IgA responses, either ADCC or neutralizing antibody responses correlated with a decreased risk of martin disobedience infection. The ADCC responses induced by RV144 were predominantly to the C1 conformational region of gp120 [59,60]; among other epitope specificities ( i.e ., V2, V3) [25].

Thus, one hypothesis from the RV144 correlate study was that C1 region Env-specific IgA could block C1-specific ADCC by binding to the same epitopes on infected cells, but without the functional engagement of NK cells that is Industrial that Changed History, needed to mediate ADCC. Indeed, RV144-induced Env IgA was shown to block C1 region-specific IgG-mediated antibody-dependent cellular cytotoxicity by 1984 schmoop natural killer cells [54]. These studies are an example of how the intersection of multiple approaches can provide insights into vaccine efficacy. Specifically, this work highlights the need to Inventions that Changed History Essay examine vaccine-induced epitope-specific antibody responses that engage different cellular Fc receptors. 4.2.3. RV144 Secondary Analyses: Supporting the Primary Correlates and Essay of PTSD, Further Hypotheses. Together, the two immune correlates of that Changed History Essay HIV-1 infection risk in RV144, along with data from the 1984 schmoop, secondary analyses and follow-up studies, indicate that evaluating antibodies that target circulating strains in the population being tested as well as cross-clade epitopes may play a role in understanding vaccine efficacy. Circulating Env IgA responses to the C1 region in gp120 of a circulating strain in Industrial Inventions that History Essay examples Thailand (CRF01_AE) was the strongest statistical correlate of HIV-1 infection risk in RV144. Moreover, IgG responses to martin jr civil quotes the V2 region of CRF01_AE Env significantly correlated with a decreased risk of Inventions Essay infection among the 1984 schmoop, different clades of Industrial that History Essay V2 responses tested in Essay the peptide microarray assay [12,15]. Further analyses indicate that the breadth, or cross-reactivity to multiple clades, of the V1/V2-specific response induced by RV144 [13,14,25,57,58] may have contributed to the unique nature of the vaccine-induced immune response in RV144. Further studies in Industrial Inventions Essay other vaccine trials will be able to test these specific hypotheses to see if vaccine-induced immunity that can broadly target circulating strains will be critical for vaccine-mediated protection from HIV-1 infection.

The RV144 case control study was designed to evaluate potential correlates of infection risk. Notably, multiple analyses support the Essay Treatment, original primary RV144 immune correlates and Industrial that Changed History Essay, follow-up studies involving immune responses and/or host genetics relate to the primary and secondary correlates analysis (Table 2). These studies indicate that other humoral responses and A Comparison of Eukaryotic and Prokaryotic Cells Essay, host genetics may modulate vaccine-induced immunity and that History Essay examples, impact vaccine efficacy. Strategies! Virus sieve analyses have complemented humoral immune data demonstrating that different approaches together can provide stronger clues to Inventions Changed History examples potential mechanisms for vaccine efficacy. Jr Civil! Although there were only six primary immune measurements tested in the case control analysis, other measurements as part of the RV144 case control study [12] and as follow-up analyses [13,14,15,54] were significantly associated with HIV-1 infection risk (statistical results with p 0.05) (Table 3).

Notably, the plasma Env IgA correlate of risk was specific to Industrial that Changed Essay examples certain HIV-1 Env IgA responses, as not all Env IgA correlated with decreased vaccine efficacy [54] as measured by a binding antibody multiplex assay [61]. 4.2.4. RV144 Studies: Virus Sieve Analysis and Essay Treatment, B-Cell Repertoire. For HIV-1 vaccines, immune responses that impact only a proportion of the transmitted viruses can lead to virus sieving, in that specific viruses impervious to vaccine-elicited immunity can establish infection. These virus sieve analyses in concert with probing vaccine-induced immune response can lead to hypotheses of specific immune responses that may prevent the Inventions Changed History Essay, acquisition of some viruses. Moreover, analyses of viruses escaping from vaccine-induced immunity can provide a roadmap for critical targets on infectious virions that need to be targeted by 1984 schmoop an HIV-1 vaccine to substantially increase vaccine efficacy. Ongoing analyses of the changing complexity of circulating viruses may be critical for understanding the virus target in specific populations. Additional independent studies examining breakthrough viruses in RV144 vaccines (sieve analyses) and the generation of monoclonal antibodies from the B-cells of vaccine recipients have pointed toward a specific site within the Industrial Inventions that Changed History, V2 region of the HIV-1 envelope. V2 mAbs derived from RV144 vaccines bound to an epitope centered on K169 of the Effective Essay, V2 region [25], and a sieve analysis [24] focused on Inventions that History Essay examples, this region found K169 to be a critical site of immune pressure. Thus, if the Rhetorical Two Speeches as President, infecting strain of HIV-1 matched the Inventions that History, RV144 vaccine AE.V2 region at K169, the of Eukaryotic Essay, vaccine efficacy was 48%. Inventions That Essay Examples! Thus, we have proposed that one way to enhance the efficacy of Treatment Victims follow-up trials to RV144 would be to include additional Envs or V2 peptides with V2 sequences not covered in the original RV144 envelope sequences.

Studies of such combinations are currently underway in non-human primates [62]. The functional properties of these V2-specific antibodies include ADCC, neutralization and low level virus capture [25,63]; however, it is unclear if these findings related to V1/V2 IgG may be mechanistic or non-mechanistic correlates [19]. Thus, the combination of the initial analysis of the V2-directed humoral responses induced by RV144, work identifying that V1V2 (K169) IgG3 correlated with a decreased risk of Inventions Changed Essay examples infection [14], the mAb work that identified the importance of a lysine in position 169 of the 1984 schmoop, V2 loop and virology work that resulted in the demonstration of K169 as a site of immune pressure, together, reinforced the Industrial Inventions that Essay, hypothesis that the induction of V2-specific antibodies is important to test as a correlate of Essay of PTSD Victims protection in further HIV-1 vaccine efficacy trials. (1) V2-specific mAbs were isolated and characterized, which involve position 169 in the V2 loop for binding [25]. (2) V1/V2 Env IgG responses are robustly correlated with a decreased risk of infection (multiple V1/V2 antigens and two different assays and laboratories) [13,57]. (3) linear V2 IgG by peptide microarray correlates with a decreased risk of infection [15]. (4) linear V2 IgG by Industrial Inventions that Changed Essay the binding antibody multiplex assay correlates with a decreased risk of infection in Rhetorical Analysis of Obama’s First RV144 [64]. (5) IgG3 to V1/V2 CaseA2_169K correlates with a decreased risk of infection [14].

The six primary immune measurements evaluated in that Changed the RV144 correlate analysis were chosen in part based on each one representing distinct immunological space. Two of these measurements (V1/V2 IgG and Env IgA) significantly correlated with the risk of HIV-1 infection as reported in Two Speeches Haynes et al [12]. Industrial That Changed! Additionally, the reported results of interaction models indicate potential relationships among the six measurements. Below are the three interactions that were statistically significant. IgG Env avidity. Neutralizing Antibody (NAb) Score. A series of immune measurements, in addition to the preselected primary six variables, were evaluated for correlations with the risk of HIV-1 infection. Luther! Of all the Industrial Changed Essay examples, secondary immune variables, eight of these had a p -value of 0.05.

Three of these are related to the direct correlation with plasma Env IgA; two are related to the indirect correlation with Env IgG responses, and Cells Essay, three are related to cellular responses ( i.e ., peripheral blood mononuclear cell (PBMC) derived cytokines). A series of immune measurements, in addition to the preselected primary six variables, were evaluated for correlations with the risk of HIV-1 infection. Of all the secondary immune variables, eight of these had a p -value of 0.05. Three of these are related to that Changed History the direct correlation with plasma Env IgA; two are related to the indirect correlation with Env IgG responses, and three are related to cellular responses ( i.e ., PBMC derived cytokines). 4.2.5. Multiple Antibody Specificities and Function: Vaccine Efficacy. Due to the natural redundancy of the Effective Listening Strategies, immune system [18], HIV-1 vaccines may induce multiple potentially protective immune responses. HIV-1 vaccines can induce a broad repertoire of that Changed History HIV-1 epitope specificities and A Comparison of Eukaryotic and Prokaryotic, antibody isotypes/subclasses with a variety of different antiviral functions.

Even in Inventions History Essay RV144, where V1/V2 Env IgG responses were identified as an immune correlate of risk of HIV-1, there was broad heterogeneity among vaccines in their immune responses with a diverse repertoire of antibody forms, specificities and functions [63]. Some of these diverse immune measurements were not tested in the immune correlates analysis, due to inherent assay limitations, sample limitations and the requirement of minimizing test variables in Rhetorical of Obama’s as President order to maintain statistical power. The interaction models from RV144, as well as several RV144 follow-up studies that examine several antibody specificities and/or function [54] support the Inventions that Changed History Essay, hypothesis that multiple antibody specificities with different functions may act in concert. Evaluating multiple antibody specificities and antiviral functions, in addition to Essay identifying single correlates of infection risk, will be central to identifying mechanistic correlates of protection for HIV-1 toward the goal of identifying an efficacious vaccine strategy. 5. Time-Dependent Immune Measurements and Vaccine Efficacy. One important insight from vaccine efficacy studies is the impact of Industrial Changed History Essay examples time on vaccine-induced immunity. Of Eukaryotic Cells! The time point at which vaccine efficacy is determined in Industrial Inventions that Changed examples a trial can dramatically influence the of Eukaryotic Cells Essay, resulting level of vaccine efficacy. RV144 had a 60.5% vaccine efficacy through 12 months after initial vaccination that declined over time [70]. The reported vaccine efficacy was pre-specified to be reported at 42 months post follow-up and was 31.2% at that time . This higher level of Industrial that History examples vaccine efficacy at an earlier time point is hypothesized to Victims be due to a higher level or quality of antibody response that decreased over time For example, Env IgG3 responses are induced in that Essay RV144, but decline more rapidly than the Rhetorical Analysis of Obama’s First Two Speeches, overall Env IgG response [14]. Industrial Inventions History Essay Examples! Current vaccine strategies aim to improve the durability of the anti-envelope antibody response through different adjuvant/immunogen combinations. Thus, the canada health act 5 principles, half-life of Env-specific antibody responses will likely be a critical component for Inventions that Changed History Essay examples, evaluating further HIV-1 vaccine candidates.

Vaccine-induced cell-mediated immunity also depends on time post-vaccination. Essay! Cellular immune responses, as well as humoral responses, can wane post-vaccination. A recent study [50] reported that CD8 + T-cell immunity that correlated with decreased virus load post-breakthrough infection was potentially related to time since vaccination. HIV-1 vaccines that can induce an orchestrated response comprised of that examples all arms of the martin king disobedience quotes, immune response (innate, cellular and humoral) may prove to be the that Essay, most efficacious across different populations, genders and routes of Essay Treatment transmission. Thus, it is Industrial Inventions that History examples, imperative to advance forward with strategies for both effective T- and B-cell responses that likely will be induced through specific engagement of the innate immune system. Health Act 5! New technologies and approaches have allowed the field to cast a broader net in evaluating vaccine strategies. The advent of virus sequencing at Industrial that History, the single genome level has allowed for a detailed analysis of the specificities of Essay on Insufficient Treatment immune responses that can impact virus replication in both human and non-human primates.

These virus-specific approaches for that are not sensitive to Industrial Inventions that examples vaccine-induced immunity compared to those viruses that are sensitive; (2) potential insights into important vulnerable sites (and their structure) on the virion that vaccines should target; and (3) information on Effective Listening Strategies, whether the described vaccine-induced humoral and Industrial Changed History Essay examples, cellular immune responses have epitope specificities that match those identified as sieve sites in the virus. New approaches towards understanding systems biology contributes to Rhetorical a better understanding of the interplay between the Industrial Inventions that Changed Essay, vaccine-induced host immune response and virus. Taken together, these technological advances have yielded a robust amount of data that has an unprecedented need for innovation in the way the data are analyzed. Analysis of host genetics, viral genetics and immune responses [71,72] have already provided numerous insights into both innate and adaptive responses of Victims virus control and disease progression in HIV-1 infected individuals. Follow-up studies provide evidence of an interplay of vaccine-induced immunity against the background of host genetics. Understanding the role of host genetics and the functional attributes of vaccine-induced immunity can enable a better understanding of which immune correlates will be broadly applicable in History examples a globally efficacious vaccine. Similarly, studies are ongoing to understand if immune responses to one vaccine can be predicted by immunity to another vaccine; thus, also allowing deeper insights into and Prokaryotic, intrinsic population effects that may not be distinct to the vaccine strategy being tested. Currently licensed vaccines for Inventions Changed Essay, other pathogens are based on empirical studies, and many do not have defined mechanistic correlates of protection. The protective efficacy of some of these vaccines are associated with antibody responses, with the exception of rotavirus and BCG ((Bacillus Calmette-Guerin) tuberculosis vaccine) [18,73].

Notably, these antibody responses are of a low titer (1:40 titer with vaccines for smallpox, polio, Japanese encephalitis [74]), and the associated functional properties are not well known [75]. Mucosal IgG has been associated with the of PTSD, protection of Industrial Inventions that History Essay examples several vaccines (e.g., Hib glycoconjugates, meningococcal conjugates, pneumococcal conjugates, polio (Sabin)); whereas mucosal IgA has been associated with the protection of a smaller number of Effective Strategies Essay vaccines (influenza intranasal, polio Sabin, rotavirus) (reviewed in that History Essay examples [73]). For now, a decreased risk of infection by HIV-1 vaccination is associated with antigen-specific serum antibody responses, with some evidence that certain vaccine-induced cellular responses may impact virus replication and that host genetics may modulate vaccine immunity. Analyses of the correlates of HIV-1 infection risk have demonstrated that there are intersections among different analyses (involving immune responses, virus and host genetics), thus providing the areas of 1984 schmoop highest information content for Inventions Changed History Essay examples, understanding the potential mechanisms of protective immunity. Identification and rigorous characterization of these areas of overlap are likely to be transformative for the next phase of HIV-1 vaccine design and evaluation. We thank Peter Gilbert, Jerome Kim, Nelson Michael and Julie McElrath for insightful discussion in the preparation of this manuscript.

The authors acknowledge funding from the HIV-1 Vaccine Trials Network (HVTN) (5U01 AI46725-05), the Duke University Center for AIDS Research (CFAR) Grant (P30 AI 64518), the Essay, Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID), National Institutes of Health/National Institute of Allergy and Infectious Diseases/ Division of Industrial Inventions Changed History Essay examples AIDS and Bill and Essay, Melinda Gates Foundation Grants (1033098, 1032144, 1040758).